Hiroya Ishihara
Applications Scientist
Mr. Hiroya Ishihara is an Application Scientist at Olympus. He was studying the epigenetic factors involved in plant regeneration using omics and microscopy in Tokyo University of Science. Confocal and two-photon microscopy were his trusted partner at that time. Therefore, he joined Olympus to make life science more exciting with microscopes. Currently, he is working on a wide range of projects from basic research to product/sales strategy.
Artículos
Análisis de imágenes tridimensionales de alto rendimiento de organoides y esferoides derivados de pacientes
Hiroya Ishihara - martes, 11 mayo, 2021
Applications Scientist
Olympus Technologies Asia, Olympus Corporation
Los organoides y esferoides pueden reproducirse con mayor fidelidad en condiciones in vivo, y el análisis basado en el procesamiento de imágenes permite monitorear las respuestas específicas de las células con alta resolución espacial. Por lo tanto, se han ido desarrollando análisis tridimensionales y métodos de evaluación de fármacos basados en el procesamiento de imágenes gracias a organoides y esferoides tumorales derivados de pacientes.
NoviSight™ Demonstration: 3D Image Analysis and Statistical Software for Organoids and Spheroids
Hiroya Ishihara - martes, 7 septiembre, 2021
Applications Scientist
Olympus Technologies Asia, Olympus Corporation
Three-dimensional cell culture models such as patient-derived organoids (PDO) and spheroids have increased in popularity because they can provide a 3D microenvironment that more closely reproduces in vivo conditions compared to 2D monolayer culture. Phenotypic and functional heterogeneity arise among cancer cells within the same tumor because of genetic change, environmental differences and reversible changes in cell properties. Therefore, evaluation of cell-specific responses is important for accurate prediction of drug efficacy and kinetics in vivo.