Total internal reflection fluorescence microscopy (TIRFM) has firmly established itself over the last few years as a key technique in the investigation of molecular interactions at or near the cell surface. Olympus is experienced in providing advanced TIRFM solutions and cellTIRF takes this to the next level with a series of peerless features such as highly advanced optics, unique independent laser control and exceptional accuracy. The cellTIRF system is easy to use for TIRFM, HILO microscopy and point FRAP for a range of experimental protocols.