Drug Discovery

Life Science Research Application

Pharmaceutical companies use cell models for their research as an alternative to animal experiments and for more precise evaluation of drug efficacy. In recent years, 3D cell models called spheroids, organoids, and “body-on-a-chip” have been engineered and applied to pharmaceutical research. We provide not only conventional brightfield observation solutions but also confocal microscopes and multiphoton excitation microscopes for deep specimen image acquisition, enabling high-resolution observation of 3D structures. To prepare for cell model construction, it is important to keep the quality and number of cells constant, so we also offer reliable cell culture solutions. Our slide loader system and analysis solutions can acquire high-speed, high-resolution images of an entire section of tissue for high-precision pharmacology and drug efficacy analysis.

Cell Counting–Measuring the Number of Cells in Spheroids

Evaluation of Drug Efficacy–The Response of Spheroids to a Drug

Evaluation of Drug Efficacy–Quantitative Evaluation of Spheroid Size

Analysis of Anticancer Drugs-Targeting the Interior of Spheroids

Response to Drug Treatment-Cell Cycle Analysis of 3D Cell Cultures

Response to Drugs–Inside and Outside of 3D Cell Cultures

Evaluation of Drug Efficacy–The Response of Co-Cultured Spheroids to Drugs

The Response of Mitochondria in Cancer Spheroids to Drugs

Fluorescent Image Analysis–Live Dead Cell Assay of Spheroids

Fluorescent Image Analysis–3D Spheroid Invasion in a Collagen Gel

Fluorescent Image Analysis–Cell Division in Spheroids

3D Time-Lapse Imaging of Spheroids with the FLUOVIEW FV3000 Confocal Microscope: 48-Hour Continuous Observation of Antibody-Dependent Cell-Mediated Cytotoxicity (ADCC)

Identifying Collagen Fiber Types I and III Stained with Picrosirius Red Using the BX53 Microscope Equipped with Olympus’ High Luminosity and High Color Rendering LED

3D Analysis of Patient-Derived Tumor Organoids

True 3D Analysis of an Intracellular Autophagic Pathway in a 3D Spheroid Model

3D Spatial Analysis of High-Throughput Drug Screening

Analysis Workflow for 3D Live/Dead Cell Assays

Label-Free Transmigration Assay Using scanR TruAI for Self-Learning Microscopy

Imaging of Drug Response in Drug Efficacy Assessment

Verifying the Tumor Labeling of a Novel Fluorescent Nanoprobe Using NIR Imaging

Drug Viability Testing of 3D Cancer Spheroids Using Automated Macro-to-Micro Imaging

An Introduction to the Gradient Contrast Method

How the APX100 Microscope’s Smart Sample Navigator Improves Pre-Observation Workflow Efficiency

Microscope System/Frame

FV5000

Confocal Laser Scanning Microscope

Extraordinary clarity, speed, and reliability driven by groundbreaking innovations
SilVIR™ detectors deliver photon-level quantitation, exceptional sensitivity, and ultra-high signal-to-noise
Unmatched dynamic range captures the full signal spectrum and prevents saturation
High-speed 2K resonant scanning and high-density 8K galvo scanning in one platform
FLUOVIEW Smart™ software simplifies operation with intuitive controls and AI-powered automation
TruResolution™ auto correction collar optimizes focus for over 20 objectives
Modular design supports up to 10 laser lines and future multiphoton upgrades
Laser Power Monitor (LPM) ensures stable illumination and reproducible results over time

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FV5000MPE

Multiphoton Laser Scanning Microscope

Compact fiber-pigtailed lasers enable deep, quantitative imaging in scattering tissue
One-, two-, or three-line simultaneous MPE laser excitation for millimeters deep imaging
SilVIR™, TruAI, and TruSight™ technologies deliver outstanding signal-to-noise and clarity
MPE-optimized objectives, TruResolution™ auto correction collar, and automated IR laser alignment maintain sharp focus
Available as an FV5000 system upgrade or a complete MPE system
Fully tunable laser configurations available for more advanced multiphoton applications

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FV4000