High-Resolution Microscope Slide Scanners

Brain Research

Brain and neuroscience researchers often need to examine a wide range of samples—from individual cells to entire tissues or organs, such as the brain. The VS200 slide scanner delivers high-resolution scans of entire brain samples by seamlessly combining the data from multiple images into a single digital file. A large glass slide holder can accommodate larger specimens—such as monkey brains—enabling full digitization in a single scan.

^{Corticothalamic projection pathways labeled with AAV-GFP and AAV-tdTomato.
Image data courtesy of Hong Wei Dong, MD, PhD, Professor of Neurology, Keck School of Medicine of University of Southern California.}

_{Lung adenocarcinoma labeled for pan-CK, CD276, CD31, and CD68.
Sample courtesy of HistologiX.}

Cancer and Stem Cell Research

In cancer and stem cell research, accurately evaluating tissue composition and cellular morphology is essential. This includes the ability to resolve individual cells and distinguish closely spaced or overlapping structures (localization). The VS200 system’s advanced optics provide broad chromatic aberration correction and enhanced flatness, making it easier to resolve target molecules while significantly minimizing image distortion.

Drug Discovery

In drug discovery research, gaining insight into target molecule interactions often relies on detecting the localization of multiple molecules simultaneously. High image quality is essential for acquiring accurate quantitative data from whole slide images—and this is where the VS200 slide scanner excels. By capturing positional information for multiple target molecules across a wide area in a single scan, the system enables efficient evaluation of molecular interactions.

^{Pancreas stained with DAPI, GFP, and RFP.}

^{Image data courtesy of Wenjin Chen, Rutgers Cancer Institute, New Jersey.}

^{VS-SILA image of an organoid sample acquired at 20X. A Z-series of 20 µm thickness is acquired and processed with extended focus imaging (EFI). The organoid was imaged with 405 nm, 488 nm, 561 nm, and 638 nm excitation.
Samples provided by a customer in Europe.}

Organoids

3D structures that mimic real organs, organoids are important tools in stem cell research. The VS-SILA optical sectioning device aids organoid research by enabling users to image most sample types, including cleared and fixed cells and tissues thicker than 100 microns, with any magnification.

Botany and Plant Research

Plant research is fundamental to obtain insights into the science behind agriculture and environmental protection. Using the VS200 scanner's batch mode, researchers can quickly screen for mutant phenotypes.

^{Section of a VS-SILA extended focus image (EFI) acquired at 20X magnification, showing a close-up view of a 12 µm lily flower bud. Yellow and red: autofluorescence signal at 561 nm and 638 nm excitation.}

^{H&E stained tissue, 40X.}

Digital Pathology

Digital pathology uses whole‑slide imaging to convert glass histology slides into high‑resolution digital files that can be viewed, shared, and analyzed on a computer. Slide scanners are the core enabling technology, rapidly capturing entire tissue sections with consistent quality and reproducibility. Together, they support remote diagnosis, multidisciplinary collaboration, and the application of AI algorithms for quantitative analysis, improving efficiency and diagnostic confidence in pathology workflows.